Sodium Valproate BP
Composition : Sodium Valproate BP 200 mg.
Indications : It is indicated for the
treatment of all types of epilepsy, e.g.
partial seizures, absence seizures, generalized tonic-clonic seizures, myoclonic seizures, atonic
seizures, mixed seizures that include
absence attack.
Dosage and Administration : Epilepsy:
Adults: Initially 600mg daily in 2 divided
doses, preferably after food, increased
by 200mg at 3 days intervals to
maximum 2.5gm per day in divided
doses until control of seizure is
achieved. Usual maintenance dose: 1-
2gm daily (20-30mg/kg daily). Children
bodyweight up to 20kg: Initially
20mg/kg daily in divided doses, may be
increased provided plasma concentration
monitored (dose above 40mg/kg daily
also monitor clinical chemistry and
haematological parameters). Children
under 12 years bodyweight over 20kg:
Initially 400mg daily in divided doses
increased according to response (usual
range 20-30mg/kg daily), maximum
35mg/kg daily. Or, as directed by the
registered physician.
Use in pregnancy and lactation : Sodium valproate crosses the placenta in humans; exposure to valproate in the first trimester causes neural tube defects such as anencephaly and spina bifida in newborn. Sodium valproate is excreted in human breast milk. It is not known what effect this would have on a breastfed infant. This drug should be used during pregnancy & lactation only if clearly needed.
Packing : Nalipsy Tablet: Each box contains 10x10's tablets in blister pack.