Doxorubicin HCL USP
Composition :
Dobixin- 10: Each vial (5 ml) contains Doxorubicin Hydrochloride USP 10 mg
Sterile Injectable Solution for Intravenous use.
Dobixin- 50: Each vial (25 ml) contains Doxorubicin Hydrochloride USP 50 mg
Sterile Injectable Solution for Intravenous use.
Indications : It is indicated for the treatment of acute lymphoblastic & myeloblastic
leukemia, Hodgkin & non-Hodgkin lymphoma (NHL), metastatic breast cancer,
metastatic Wilms' tumor, metastatic neuroblastoma, metastatic soft tissue
sarcoma, metastatic bone sarcoma, metastatic ovarian carcinoma, metastatic
transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic
gastric carcinoma & metastatic bronchogenic carcinoma.
Dosage and administration:
Adjuvant Breast Cancer:
The recommended dose is 60 mg/m2 administered as an intravenous bolus on day 1 of each 21-day treatment cycle, in combination with cyclophosphamide, for a total of four cycles.
Metastatic Disease, Leukemia, or Lymphoma
i) The recommended dose of Doxorubicin HCI when used as a single agent is 60 to 75 mg/m2 intravenously every 21 days.
ii) The recommended dose when administered in combination with other chemotherapy drugs, is 40 to 75 mg/m2 intravenously every 21 to 28 days.
iii) Consider use of the lower Doxorubicin dose in the recommended dose
range or longer intervals between cycles for heavily pretreated patients, elderly
patients, or obese patients.
iv) Cumulative doses above 550 mg/m2 are associated with an increased risk of cardiomyopathy. Or, as directed by the registered physicians. Please see prescribing description for more information.
Use in pregnancy and lactation : Pregnancy Category D. There are no adequate and well-controlled studies in
pregnant women. If Doxorubicin is to be used during pregnancy, or if the
patient becomes pregnant during therapy, the patient should be apprised of
the potential hazard to the fetus. Women of childbearing age should be
advised to avoid becoming pregnant.
Packing :
Dobixin- 10: Each box contains one vial of Doxorubicin Hydrochloride USP 10 mg Sterile Solution.
Dobixin- 50: Each box contains one vial of Doxorubicin Hydrochloride USP 50 mg Sterile Solution.